● Drug Name: Pazopanib Manufacturer ● Chemical formulation: C21H23N7O2S ● Active ingredient: Votrient ● Common/generic brand name: Votrient ● Approved by FDA: Yes ● Commonly marketed: China ● Density: 1.40 g/cm3

Pazopanib is a drug used to fight against metastasis. Commonly it is sold as Votrient or Pazopanib Hydrochloride. It is classified as Tyrosine Kinase inhibitors. According to experimental studies, Pazopanib halts endothelial cell production and fibroblastic cell proliferation. It has the unique ability to bind with the protein that produces resistance in the growth of the tumor cells This is achieved by cutting off the blood supply to the metastatic cells, halting the production of the neoplastic cells. It is used for treating renal cell carcinoma (kidney cancer) and soft tissue sarcoma, both on advanced levels. Patients with soft tissue sarcoma who are already treated with chemotherapy are mostly treated with this pharmaceutical drug. Pazopanib is popular for large-scale successful results when introduced to patients of renal cell carcinoma and soft tissue sarcoma, reported from different areas of the world. It is also cost-effective enabling one to adopt a manageable treatment regimen rather than highly expensive alternatives like surgery or transplant.

It is generally supplied by Novartis Pharmaceuticals Corporation, Novartis Europharm Limited, and Glaxosmithkline Inc.

This pharmaceutical substance is only produced for oral administration. It is available as 200 mg film-coated tablets and 400 mg film-coated tablets.

To achieve the desired effect and to avoid any risks, it is suggested to take the 200mg tablet on an empty stomach, particularly one hour before the meal or two hours after the meal. It is important to maintain a 12-hour difference between the doses if you have missed any dose. The medicine has to be swallowed without crushing or chewing as it may increase the likelihood of the manifestation of its adverse effects. The dose should not exceed more than 800mg per day. Consult your doctor before starting the medication if you are already taking antacids or Proton-pump inhibitors (PPIs) as this drug can cause a reduction in the acid secretion in the gut. The exact dosage depends on the clinical reports, patient condition, other medications being taken by the patient, and any existing comorbidities.

● Shanghai Huirui Chemical Technology Co., Ltd. ● Hangzhou Excelente Chemicals Co., Ltd. ● Hubei Widely Chemical Technology Co., Ltd. ● Hangzhou Royall Import & Export Co., Ltd. ● HONGKONG XINRUNDE CHEMICAL CO., LTD. ● Beijing Cooperate Pharmaceutical Co., Ltd. ● Hubei Vanz Pharm Co., Ltd. ● Hangzhou Brown Bio&Pharm Co., Ltd. ● Beijing Mesochem Technology Co., Ltd. ● Guangzhou Tongyi Biochemistry Technology Co., Ltd. ● Beijing Star Technology Development Co., Ltd. ● Shenzhen TMH Technology Co., Limited ● Shanghai Yingxuan Chempharm Co., Ltd. ● Shanghai Innovation Industry Co., Ltd.

A single Pazopanib tablet of 200mg costs $126.72 whereas a whole pack containing 120 tablets costs $15,206.71.

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Pazopanib has the potential to cause significant side effects, usually, these can be mild or moderate which are either rectified with time or are manageable and prevented through medications. The adverse effects manifest in less than half of the population administered with the drug, which includes long-term effects like upset stomach, disturbed blood pressure, changes in skin or hair color, a decline in the number of blood cells, or increased bilirubin levels. The patient is likely to experience some side effects as soon as the drug is taken such as vomiting, nausea, sleeplessness, or lethargy, or headache. The subjected pharmaceutical remedy may show severe side effects in rare cases which may be irreversible and require immediate consultation of a doctor. These include elevated body temperature, yellow discoloration of the body or whitening of the eyes, burning in the mouth, hematuria (blood in urine), melena (black feces), bleeding through the rectum, burning sensation while micturating, seizures, unusual bleeding, chest pain, shortness of breath, fluctuating heart rates and muscle spasms. In extremely rare cases, it is also suspected that the drug may form clots in the blood vessels, causing venous thrombosis or pulmonary embolism, or hepatic dysfunction.

Adults are the usual recipients of Pazopanib .There has been no evidence of valid prescription for children aged below 18. Since it is used for the long-term turnover of the neoplastic cells, this process may affect the hemostatic metabolism and can cause serious complications if the proper dose isn’t prescribed. It is mandatory to regulate your medications alternatively with Pazopanib and the intake of doses with proper intervals between meals is of utmost importance. Make sure to take it on an empty stomach. Do not increase the dose on your own as this may put you at an increased risk of adverse complications. Inform your doctor about any previous or current allergies before starting the medication. The performance of Pazopanib may be affected by grapefruit juice resulting in adverse reactions and complications in the treatment. Antacids must also be avoided with this drug.

Pregnant women must not be administered this drug due to the risk of the development of congenital anomalies in the fetus. Pazopanib may cause infertility issues therefore it is highly recommended to avoid getting pregnant while on this treatment regimen. It is advised to consult your doctor if you suspect a pregnancy anytime while taking this medication. Due to its secretion in the milk, there is a risk of growth restriction of organs in the fetus. Therefore, Pazopanib should not be administered in lactating women.

1. Is Pazopanib a chemotherapeutic agent? It benefits chemotherapy but it isn't used for therapeutic procedures. 2. Is Pazopanib an immuno-suppressive drug? There is no such evidence of Pazopanib suppressing the immune system but there may be some adverse effects so caution is advised. 3. What is the best thing to eat during the medication period? Most commonly the drug causes diarrhea, to avoid it, you may eat food that is assimilated easily. 4. When should Pazopanib be taken? One tablet per day with a glass of water is adequate, also there should be a difference of 12hrs between each dose. 5. Does Pazopanib cause permanent hair loss or defective hair color? Once the treatment is ceased, the hair color and growth will be restored. Temporarily it may cause hair loss and changes in hair color.