Rilmenidine

Rilmenidine is the first antihypertensive, with selectivity for I1 imidazoline receptors. It exerts effects both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. It is a recommended first-line treatment for mild-to-moderate essential hypertension. It is similar to other BP medicines in both the short and medium-term effects but has better long-term effects on cardiovascular morbidity and mortality. Studies have shown that it has long-term benefits similar to diuretics and β-blockers, ACE inhibitors, and calcium channel blockers. Rilmenidine is sold under the brand names Albarel, Hyperium, Iterium, and Tenaxum among others. Teva pharmaceuticals were first launched Rilmenidine in 1999 in Hungary and the Czech Republic and later approved by the Russian federation in 2004.

Dosage and administration

Rilmenidine is sold as tablets for oral use. In the treatment of Hypertension, the usual recommended adult dose is 1 mg, taken daily. The dose can be increased to 2mg a day after 1 month, given in divided doses, 1 tablet morning and evening before meals. Rilmenidine can be used by both elderly and diabetic hypertensive patients. If treating patients for hypertension with kidney failure, dosage adjustment is not needed if the creatinine clearance is greater than 15 mL/min. this medicine is taken for an indefinite period of time.

The Price of Rilmenidine

In the international market, a supply of 5mg costs USD122. In Latvia, the consumers have to pay an average price of $7.78 for a supply of 30 tablets of 1mg strength.

How does it work?

Rilmenidine exerts its antihypertensive effect by lowering the total peripheral resistance, mediated by a reduction in sympathetic activity. As a Central sympatholytics, it has a variety of antihypertensive actions, that increase sodium excretion and decrease the cardiac output, heart rate, total peripheral resistance, and renin release. It crosses the blood-brain barrier and stimulates the imidazoline I1 receptors and or central postsynaptic alpha2 adrenoceptors in the brainstem’s sympathetic nervous control centers.

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