Sevelamer

Sevelamer is a drug used to treat a high level of phosphates in patients suffering from chronic kidney disease, specifically amongst patients who are on dialysis due to chronic kidney diseases. It is called a phosphate binder when taken with meals; it binds to dietary phosphate and prevents its absorption. Normally functioning kidneys are designed to remove extra phosphorus in your blood, but in patients with chronic kidney disease, the kidneys cannot remove phosphorus enough so the resulting high phosphorus levels cause damages to the body. In patients with CKD (Chronic Kidney Disease), it helps to reduce bad cholesterol and triglycerides and increases the amount of good cholesterol (HDL). Phosphate in the blood is removed in dialysis. However, even this may not bring down phosphate levels to the desired balance. It is vital to have lower phosphate levels, a decrease in blood phosphate helps maintain strong bones, acts as a preventer of the unsafe buildup of minerals in the body, thus decreasing the probability of heart disease and strokes resulting from high phosphate levels. Sevelamer and is currently marketed under the brand name Renagal amongst others. In 1998, GelTex Pharmaceuticals invented Sevelamer and got it approved by FA. Sevelamer is marketed by Sanofi under the trade names Renagel (sevelamer hydrochloride) and Renvela (sevelamer carbonate).

Forms and Dosage

Sevelamer is sold as a tablet and as a powder for the suspension to take by mouth. The tablet is sold in the strengths of 400mg and 800mg and in the powder packet for oral suspension, the strengths are 800mg and b 2400mg. in the treatment of hyperphosphataemia, in adult patients are given a standard dose of 800mg film-coated tablets.

The cost of Sevelamer

In the USA, the price of Sevelamer oral powder is around $724 for a supply of 90 days, depending on the pharmacy, insurance, and the programs that the patient is on. Whereas the same medication can cost only 50 pounds in Britain due to extensive work in the EU to bring down the price of this medication. In the developing world too, the generic version of this medication and in the USA too, in the discount pharmacies, the drug is sold for a significant discount.

How does Sevelamer work?

Sevelamer is a non-absorbable phosphate-binding crosslinked polymer, free of metal and calcium and it has multiple amines separated by one carbon from the polymer, protonated in the stomach. The pronates bind negatively charged ions like dietary phosphate in the intestine. Sevelamer lowers the phosphorus concentration in the serum by binding phosphate in the gastrointestinal tract and decreasing absorption.

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