Sulfadiazine Silver is sold under the brand name “Silvadene”, “SSD Cream”, and “Thermazene”. It belongs to the class of drug known as a sulfa antibiotic. This pharmaceutical medicine is used in conjunction with other medications to aid in the prevention and treatment of wound infections in patients with severe burns. This pharmaceutical medicine is available as a cream. It is typically applied topically, once or twice daily. Do not use more or less of it, or use it more frequently than your doctor has prescribed. Some medications which can have interaction with this drug include cimetidine, and skin products containing Sodium Sulfacetamide, enzyme products used to break down and remove the dead skin from burns and wounds (which includes collagenase, papain, trypsin). An inactive factor in a few manufacturers of this medication (Propylene Glycol) can be absorbed and can interfere with laboratory tests, potentially causing false test results. Side effects associated with this medication include pain, burning, itching, unusual bleeding or bruising, fever, sore throat, yellowing of the skin or eyes, and blood in the urine. This medication should be used only when clearly necessary during pregnancy. Because of the risk of harm to the unborn baby, this medication should not be used close to the expected delivery date. It is uncertain whether this medicine is secreted in breast milk. Similar medications, on the other hand, enter into breast milk and may affect breastfeeding infants who are unwell, premature, less than 2 months old, or have certain diseases (such as jaundice, high blood levels of bilirubin, G6PD deficiency). Breast-feeding is therefore not suggested in infants with these problems while using this medicine.

Sulfadiazine Silver inhibits the growth of microorganisms that could infect an open wound. This reduces the likelihood of the bacterium spreading to nearby skin or the bloodstream, where it can cause a serious blood infection (sepsis).

Sulfadiazine Silver topical cream 1% costs roughly $12 for a supply of 20 grams, depending on the drugstore you visit.

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