Triamcinolone Hexacetonide
Triamcinolone Hexacetonide is used to treat and manage conditions like allergic disorders,
arthritis, gout, blood diseases, breathing problems, certain cancers, eye diseases, intestinal
disorders, and collagen and skin diseases. It is also used to treat Rheumatoid arthritis,
Juvenile Idiopathic Arthritis, Osteoarthritis and post-traumatic arthritis, Synovitis, tendinitis,
bursitis, and epicondylitis. Triamcinolone is a corticosteroid hormone called glucocorticoid.
Triamcinolone Hexacetonide improves the body's immune response to these diseases and
reduces symptoms such as swelling.
Triamcinolone hexacetonide is sold under the brand name Aristospan amongst others.
Smith And Nephew Associated Companies Limited filed the first known patent for
Triamcinolone hexacetonide in 1980. Genzyme is one of the current assignees of the FDA
license.
Dosage and administration
Triamcinolone hexacetonide is sold as Suspension for injection, it is Milky white suspension,
and is easily suspendable. Every ml of the suspension for injection contains 20 mg
triamcinolone hexacetonide and 9 mg of benzyl alcohol per ml and 455 mg sorbitol per ml.
It is critical that the user is observed for Asepsis. Shake the vial to ensure suspension and
sterilize the injection site using the lumbar puncture technique. In every treatment session,
only two joints at the most are injected.
As an Intraarticular injection, the recommended dose could be between 2-20 mg. the dose is
set according to the size of the joint and the amount of articular fluid by each individual.
Large joints like hip, knee, shoulder need a dose between 10-20 mg, medium-sized joints
need a dose of 5-10 mg, and the smaller joints need a dose of 2-6 mg. it is long-acting, so
the administration should not be more frequent than once every 3-4 week interval.
The Periarticular injection formulation is given to adults and adolescents only. In the
treatment of Bursitis or Epicondylitis, the usual recommended adult dose is 10-20 mg subject
to the size of the bursa and the severity of the disease and in the treatment of Synovitis or
Tendinitis; the recommended dose is 10-20 mg. the number of injections needed is decided
based on the response from the patient.
The Price of Triamcinolone Hexacetonide
In the USA, the consumers have to Pay a retail Price of USD22.90 for a 1 milliliter of supply
and cost USD45 for a supply for 5ml of this injection.
How does Triamcinolone Hexacetonide Work?
Glucocorticoids are naturally occurring but can also be made synthetically. These are
adrenocortical steroids, which get absorbed from the gastrointestinal tract. Naturally,
occurring glucocorticoids like hydrocortisone and cortisone with salt-retaining properties
replace the adrenocortical deficiency. Glucocorticoid synthetic forms are used for anti-
inflammatory effects.
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References
https://www.medicines.org.uk/emc/medicine/28913#gref
https://www.webmd.com/drugs/2/drug-5590/triamcinolone-hexacetonide-injection/details
https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/016466s046lbl.pdf
https://www.sciencedirect.com/topics/medicine-and-dentistry/triamcinolone-hexacetonide