Vigabatrin:

Vigabatrin, also known under the popular brand name Sabril, is a medication used in the treatment of epilepsy. It was originally developed by a pharmaceutical products manufacturing company in the 1980s, with the goal to identify drugs capable of increasing GABA concentrations in the brain. It was approved for sale on the medical marketplace in the United Kingdom in 1989, followed by subsequent approval in the United States by the FDA in 2009. The difference in approval times between the two countries was due to FDA mediated delays regarding concern over certain aspects of the animal trials and discrepancies in the clinical versions.

The drug has since entered the generics drugs space in 2019, lowering the barrier for production and making it cost-effective and attractive for vigabatrin manufacturers and vigabatrin suppliers to list for sale. Currently, it is commonly found ready to order wholesale by distributors across the global marketplace at a variety of cost and price points.

Method of action of vigabatrin:

Vigabatrin functions in the treatment of epilepsy by acting on gamma-aminobutyric acid (GABA) levels in the brain. GABA is a vital inhibitory transmitter throughout the central nervous system. Therefore the potentiation of GABAergic neurotransmission is a crucial mechanism through which antiepileptic agents function in combating pathologic excitatory neurotransmission, as seen in epilepsy. As vigabatrin raises the concentrations of GABA byway of inhibition of the enzyme responsible for its breakdown and GABA aids in the prevention of abhorrent nervous transmissions, this explains the conferred medicinal effect of vigabatrin.

Form and dosage of vigabatrin:

The final form and packaging of vigabatrin are dependent on the manufacturers and suppliers, as well as the specific distributor and order. However, it can typically be found wholesale in forms including tablets, film-coated tablets, capsules, oral powders, and rectal suppositories. Typical dosing depends on age, weight, and route of administration. As such, the prescribing medical official will determine a suitable regime. Typical values for oral consumption in adults are 1g daily to a maximum of 3g per day. For the anal route, 250 mg daily to a maximum of 1.5 g daily. For further information please refer to the manufacturers’ literature or contact an accredited medical provider.

Vigabatrin on Pipelinepharma:

Currently, at the time of writing, we have found 1 verified vigabatrin provider located in Argentina from our online global list of B2B sellers. These manufacturers, suppliers, and distributors and their pharmaceutical products lists have been verified by the Pipelinepharma team to ensure reputability. This process is time-intensive and our online global marketplace is constantly being updated. As such, it is likely that there are vigabatrin manufacturers and vigabatrin suppliers still awaiting approval and will appear shortly.

Price of vigabatrin and how to buy:

A cursory search online reveals an approximate wholesale cost of vigabatrin to be £44.41 for 100 x 500 mg tablets. With a lower price of £24.60 for 50 x 500 mg sachet. These values are indicated exclusively for the NHS in the UK using the drug tariff Part VIIIA Category C. As such they are only intended to serve as a generalization of the current market conditions in a specific area.

Although the prices on the B2B wholesale Pipelinepharma marketplace remain confidential between both B2B parties, the seller may choose to list the desired price to facilitate the online transaction. If so, an ‘Accept’ and ‘Negotiate’ button will be displayed through the online interface, with a ‘Get offer’ button being shown in the absence.